Telemonitoring of daily activity and symptom behavior in patients with COPD

Objectives. This study investigated the activity behavior of patients with COPD in detail compared to asymptomatic controls, and the relationship between subjective and objective activities (awareness), and readiness to change activity behavior. Methods. Thirty-nine patients with COPD (66.0 years; FEV(1)% predicted: 44.9%) and 21 healthy controls (57.0 years) participated. Objective daily activity was assessed by accelerometry and expressed as amount of activity in counts per minute (cpm). Patients' baseline subjective activity and stage of change were assessed prior to measurements. Results. Mean daily activity in COPD patients was significantly lower compared to the healthy controls (864 ± 277 cpm versus 1162 ± 282 cpm, P < 0.001). COPD patients showed a temporary decrease in objective activities in the early afternoon. Objective and subjective activities were significantly moderately related and most patients (55.3%) were in the maintenance phase of the stages of change. Conclusions. COPD patients show a distinctive activity decrease in the early afternoon. COPD patients are moderately aware of their daily activity but regard themselves as physically active. Therefore, future telemedicine interventions might consider creating awareness of an active lifestyle and provide feedback that aims to increase and balance activity levels

Randomized controlled trial of a good practice approach to treatment of childhood obesity in Malaysia: Malaysian childhood obesity treatment trial (MASCOT)

Context. Few randomized controlled trials (RCTs) of interventions for the treatment of childhood obesity have taken place outside the Western world. Aim. To test whether a good practice intervention for the treatment of childhood obesity would have a greater impact on weight status and other outcomes than a control condition in Kuala Lumpur, Malaysia. Methods. Assessor-blinded RCT of a treatment intervention in 107 obese 7- to 11-year olds. The intervention was relatively low intensity (8 hours contact over 26 weeks, group based), aiming to change child sedentary behavior, physical activity, and diet using behavior change counselling. Outcomes were measured at baseline and six months after the start of the intervention. Primary outcome was BMI z-score, other outcomes were weight change, health-related quality of life (Peds QL), objectively measured physical activity and sedentary behavior (Actigraph accelerometry over 5 days). Results. The intervention had no significant effect on BMI z score relative to control. Weight gain was reduced significantly in the intervention group compared to the control group (+1.5 kg vs. +3.5 kg, respectively, t-test p &lt; 0.01). Changes in health-related quality of life and objectively measured physical activity and sedentary behavior favored the intervention group. Conclusions. Treatment was associated with reduced rate of weight gain, and improvements in physical activity and quality of life. More substantial benefits may require longer term and more intensive interventions which aim for more substantive lifestyle changes

North-south asymmetry in activity on the Sun and cosmic ray density gradients

The marked N-S asymmetry in solar activity (with predominant activity in the Sun's Northern Hemisphere) during the 1960's could certainly account for a S-pointing cosmic ray gradient. It is also clear from the data that the response to this change in solar activity asymmetry, and the related change in the perpendicular cosmic ray density gradient, is different for cosmic ray telescopes in the Earth's Northern and Southern Hemispheres. Northern Hemisphere detectors see a S-pointing gradient in the 60's and a N-pointing gradient after 1971, while Southern Hemisphere telescopes see a S-pointing gradient both before and after the reversal

Fit Into College: A Program to Improve Physical Activity and Dietary Intake Lifestyles Among College Students

The purpose of this study was to determine whether a 10-week program could improve physical activity, physical fitness, body weight, dietary intake, and perceptions of exercise and diet among college 30 healthy college freshmen. Outcomes were measured at baseline, and following the 10-week program. The weekly sessions incorporated constructs of the Transtheoretical Model of Health Behavior Change and were administered by fitness interns who were junior or senior college students enrolled in health-related majors. The participants presented with low physical activity, physical fitness, and poor dietary intake, and 50% were overweight/obese (BMI \u3e 25). Participants demonstrated gains in their physical fitness and their perceived benefits to engaging in exercise and decreased their perceived barriers to engaging in exercise and a healthy diet. College freshmen presented with low levels of physical activity, poor dietary intake, and excess body weight. A peer-administered program can improve these measures and favorably change perceptions of exercise and diet

Livelisystems: a conceptual framework integrating social, ecosystem, development and evolutionary theory

Human activity poses multiple environmental challenges for ecosystems that have intrinsic value and also support that activity. Our ability to address these challenges is constrained, inter alia, by weaknesses in cross disciplinary understandings of interactive processes of change in socio-ecological systems. This paper draws on complementary insights from social and biological sciences to propose a ‘livelisystems’ framework of multi-scale, dynamic change across social and biological systems. This describes how material, informational and relational assets, asset services and asset pathways interact in systems with embedded and emergent properties undergoing a variety of structural transformations. Related characteristics of ‘higher’ (notably human) livelisystems and change processes are identified as the greater relative importance of (a) informational, relational and extrinsic (as opposed to material and intrinsic) assets, (b) teleological (as opposed to natural) selection, and (c) innovational (as opposed to mutational) change. The framework provides valuable insights into social and environmental challenges posed by global and local change, globalization, poverty, modernization, and growth in the anthropocene. Its potential for improving inter-disciplinary and multi-scale understanding is discussed, notably by examination of human adaptation to bio-diversity and eco-system service change following the spread of Lantana camera in the Western Ghats, India

EQUITY, ECONOMIC SCALE, AND THE ROLE OF EXCHANGE IN A SUSTAINABLE ECONOMY

This paper explores these theoretical and practical issues, considering the question of the environmental and ecological impacts of economic activity from the viewpoint of the scale at which this activity takes place and the exchanges across time and space which affect its sustainability. Following a consideration of the dynamics of economic change in the next section, the paper discusses the meaning of trade/exchange, economic scale, and political/ecological/economic boundaries before returning in the final section to the two equity-related issues outlined above.This research was supported by the International Development Research Centr

Tendinosis develops from age- and oxygen tension-dependent modulation of Rac1 activity.

Age-related tendon degeneration (tendinosis) is characterized by a phenotypic change in which tenocytes display characteristics of fibrochondrocytes and mineralized fibrochondrocytes. As tendon degeneration has been noted in vivo in areas of decreased tendon vascularity, we hypothesized that hypoxia is responsible for the development of the tendinosis phenotype, and that these effects are more pronounced in aged tenocytes. Hypoxic (1% O2 ) culture of aged, tendinotic, and young human tenocytes resulted in a mineralized fibrochondrocyte phenotype in aged tenocytes, and a fibrochondrocyte phenotype in young and tendinotic tenocytes. Investigation of the molecular mechanism responsible for this phenotype change revealed that the fibrochondrocyte phenotype in aged tenocytes occurs with decreased Rac1 activity in response to hypoxia. In young hypoxic tenocytes, however, the fibrochondrocyte phenotype occurs with concomitant decreased Rac1 activity coupled with increased RhoA activity. Using pharmacologic and adenoviral manipulation, we confirmed that these hypoxic effects on the tenocyte phenotype are linked directly to the activity of RhoA/Rac1 GTPase in in vitro human cell culture and tendon explants. These results demonstrate that hypoxia drives tenocyte phenotypic changes, and provide a molecular insight into the development of human tendinosis that occurs with aging

Technological Change and the Environment

Environmental policy discussions increasingly focus on issues related to technological change. This is partly because the environmental consequences of social activity are frequently affected by the rate and direction of technological change, and partly because environmental policy interventions can themselves create constraints and incentives that have significant effects on the path of technological progress. This paper, prepared as a chapter draft for the forthcoming Handbook of Environmental Economics (North-Holland/Elsevier Science), summarizes for environmental economists current thinking on technological change in the broader economics literature, surveys the growing economic literature on the interaction between technology and the environment, and explores the normative implications of these analyses. We begin with a brief overview of the economics of technological change, and then examine three important areas where technology and the environment intersect: the theory and empirical evidence of induced innovation and the related literature on the effects of environmental policy on the creation of new, environmentally friendly technology; the theory and empirics of environmental issues related to technology diffusion; and analyses of the comparative technological impacts of alternative environmental policy instruments. We conclude with suggestions for further research on technological change and the environment.technological change, induced innovation, environment, policy

Premotor cortex encoding of dynamic hand force and motor output observation underlying hand-object interaction

We studied encoding of hand force and its relations with observation-related activity in macaques trained in an isometric hand-force application and recalibration task, that required to move a visual cursor on a screen toward eight peripheral targets by exerting a force on an isometric joystick, in absence or presence of an opposing force field. Monkeys also observed the result of their action in play-back, as motion of a visual cursor on the screen. This approach combined in a single experiment isometric action performance and force adjustment with observation of its consequences in the external world, also allowing to determine whether PMd neuronal populations reflected an inverse model that specified the force necessary to move in different directions a visual object, or a forward computation encoding its desired trajectory in visual space. We found that a population of PMd cells encoded the direction of dynamic force and its recalibration when the force condition changed but did not retain memory of such change, probably reflecting an adaptation rather than a learning process. Cells with observation-related activity also modulated by change in hand force were not modulated when the force conditions changed, suggesting that their activity reflected the motion of the visual cursor on the screen, therefore the consequences of force application in the visual space. These results also allow a direct comparison of the relative contribute of different populations of PMd cells with that of cells with similar activity profile in the encoding of hand force and its consequences in the parieto-frontal system

Solar modulation in surface atmospheric electricity

The solar wind modulates the flux of galactic cosmic rays impinging on Earth inversely with solar activity. Cosmic ray ionisation is the major source of air’s electrical conductivity over the oceans and well above the continents. Differential solar modulation of the cosmic ray energy spectrum modifies the cosmic ray ionisation at different latitudes,varying the total atmospheric columnar conductance. This redistributes current flow in the global atmospheric electrical circuit, including the local vertical current density and the related surface potential gradient. Surface vertical current density and potential gradient measurements made independently at Lerwick Observatory,Shetland,from 1978 to 1985 are compared with modelled changes in cosmic ray ionisation arising from solar activity changes. Both the lower troposphere atmospheric electricity quantities are significantly increased at cosmic ray maximum(solar minimum),with a proportional change greater than that of the cosmic ray change